By Muliere P., Petrone S.
His paper appears to be like at a brand new method of the matter of discovering the maximal tolerated dose (or optimum dose, Eichhorn and Zacks, 1973) of sure medicines which as well as their healing results have secondary damaging effects.The challenge is investigated in a sequential environment from a Bayesian predictive process. seek strategies are proposed for parametric and nonparametric versions.
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A bayesian predictive approach to sequential search for an optimal dose: Parametric and nonparametric by Muliere P., Petrone S.